منابع مشابه
Ex vivo expansion of human umbilical cord blood-derived T-lymphocytes with homologous cord blood plasma.
This study was designed to establish a more effective and safe culture system for adoptive immunotherapy by investigating the use of homologous cord blood plasma (HCBP) instead of fetal bovine serum (FBS), which has various limitations including ethical problems for the ex vivo expansion of human umbilical T lymphocytes. Fresh human umbilical mononuclear cell fractions were isolated by Ficoll-H...
متن کاملEx Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells on Collagen- Fibronectin Coated Electrospun Nano Scaffold
Background and Objective: Umbilical Cord blood (UCB) hematopoietic stem cell (HSC) transplantation is a therapeutic approach for the treatment of malignant and non-malignant hematologic disorders due to ease of collection, lack of risk for donors and lower levels of infection. Moreover, it is considered a good alternative for bone marrow HSC transplantation. The main limitation of their use is ...
متن کاملex vivo-expansion of cord blood cells and its clinical application
cord blood is a rich source of hematopoietic stem cells and could be potentially used for transplantation instead of conventional sources of stem cells (bone marrow or peripheral blood). cord blood cells are successfully used in pediatric and adult patients, but their major limitation is the low number of hematopoietic stem cells for patients of large body size. there are several possible solut...
متن کاملIsolation of Endothelial Progenitor Cells from Cord Blood and Induction of Differentiation by Ex Vivo Expansion
Endothelial progenitor cells (EPCs) have been reported to possess the capacity to colonize vascular grafts and hold promise for therapeutic neovascularization. However, limited quantities of EPCs have been the major factor impeding effective research on vasculoangiogenesis. In this study, cytokine and culture conditions necessary for the provision of large quantities of endothelial cells (ECs) ...
متن کاملPromoting Effects of Heparin on ex vivo Expansion of Megakaryocytopoiesis from Human Cord Blood CD34+ Cells.
INTRODUCTION Transfusion of ex vivo expanded megakaryocytes (MKs) has been proposed to sustain platelet recovery after cord blood (CB) hematopoietic stem cell transplantation. In this study, we investigated the effects of heparin on ex vivo colony forming unit-megakaryocytes (CFU-MKs) and MKs expansion from CB CD34+ cells. METHODS CB CD34+ cells were stimulated by a combination of thrombopoie...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2009
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2009.284